AFM Imaging Reveals Multiple Conformational States of ADAMTS13.

Shanshan YuWang LiuJinhua FangXiaozhong ShiJianhua WuYing FangJiangguo Lin

Published in: Journal of biological engineering (2019)

Both WT- and GOF-ADAMTS13 exist multiple conformational states and lower pH might alter the tertiary structure and/or disrupt the intra-domain interactions, increasing the flexibility of ADAMTS13 molecules.

Keyphrases

molecular dynamics
molecular dynamics simulations
single molecule
high resolution
atomic force microscopy
high speed