Bile extracellular vesicles from end-stage liver disease patients show altered microRNA content.

Suguru NakashikiSatoshi MiumaHiroyuki MishimaHiroshi MasumotoMasaaki HidakaAkihiko SoyamaYasuko KandaMasanori FukushimaMasafumi HaraguchiRyu SasakiHisamitsu MiyaakiTatsuki IchikawaMitsuhisa TakatsukiSusumu EguchiKoh-Ichiro YoshiuraKazuhiko Nakao

Published in: Hepatology international (2021)

Secretion of EVs into the bile and their miRNA content increase in the ESLD state. Additionally, miRNA levels in bile EVs are not correlated with those in serum EVs. Bile EVs could be promising novel biomarkers for liver diseases.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis