Early Aβ reduction prevents progression of cerebral amyloid angiopathy.
Juliane SchelleBettina M Wegenast-BraunSarah K FritschiStephan A KaeserNina JährlingDaniel EickeAngelos SkodrasNatalie BeschornerUlrike ObermuellerLisa M HäslerDavid P WolferThomas MuegglerDerya R ShimshekUlf NeumannHans-Ulrich DodtMatthias StaufenbielMathias JuckerPublished in: Annals of neurology (2019)
This is the first study showing that Aβ reduction at early disease time points largely prevents CAA in the absence of parenchymal amyloid. Our observation provides a preclinical basis for Aβ-reducing treatments in patients at risk of CAA and in presymptomatic HCHWA-D. ANN NEUROL 2019;86:561-571.