Urine tricarboxylic acid cycle metabolites and risk of end stage kidney disease in patients with type 2 diabetes.

Jian-Jun LiuSylvia LiuHuili ZhengJanus LeeResham L GurungClara ChanLye Siang LeeKeven AngJianhong ChingJean-Paul KovalikSubramaniam TavintharanChee Fang SumKumar SharmaThomas M CoffmanSu Chi Lim

Published in: The Journal of clinical endocrinology and metabolism (2024)

Urine fumarate and citrate predict the risk for progression to ESKD independent of clinical risk factors and other urine metabolites. These two metabolites in TCA cycle pathway may play important roles in the pathophysiological network underpinning progressive loss of kidney function in patients with type 2 diabetes.

Keyphrases

ms ms
risk factors
multiple sclerosis