One-Pot High-throughput Synthesis of N 3-Substituted 5-Arylidene-2-Thiohydantoin Amides and Acids.
Chelsi WhitelyYangmei Li
Published in: Tetrahedron letters (2022)
A one-pot high-throughput solid-phase method for the synthesis of N 3-substituted 5-arylidene-2-thiohydantoin amide and acid has been developed. A tandem ring-closure and ring-open pathway is proposed as the mechanism of forming the two products.