Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest.

Lin PiaoYong-Hu FangManfred M KublerMichael W DonninoWillard W Sharp

Published in: PloS one (2017)

Enhanced PDH activity in the setting of TH or DCA administration is associated with improved post-CA resuscitation outcomes. PDH is a promising therapeutic target for improving post-CA outcomes.

Keyphrases

cardiac arrest
cardiopulmonary resuscitation
left ventricular
heart failure
protein kinase
septic shock