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In Vitro Susceptibility of Clinical Staphylococcus aureus Small-Colony Variants to β-Lactam and Non-β-Lactam Antibiotics.

Evgeny A IdelevichAndré KriegeskorteNina SchleimerGeorg PetersChristof von EiffKarsten Becker
Published in: Antimicrobial agents and chemotherapy (2018)
The Staphylococcus aureus small-colony variant (SCV) phenotype has been associated with relapsing and antibiotic-refractory infections. However, little is known about the activities of antibiotics on clinical SCVs. Here, we demonstrated that SCVs without detectable auxotrophies were at least as susceptible to most β-lactam and non-β-lactam antibiotics in vitro as their corresponding clonally identical strains with a normal phenotype. After prolonged incubation, a regrowth phenomenon has been observed in gradient diffusion inhibition zones irrespective of the strains' phenotype.
Keyphrases
  • staphylococcus aureus
  • gram negative
  • escherichia coli
  • multiple sclerosis
  • biofilm formation
  • copy number
  • rheumatoid arthritis
  • dna methylation
  • systemic lupus erythematosus
  • pseudomonas aeruginosa
  • cystic fibrosis