The CRK2-CYC13 complex functions as an S-phase cyclin-dependent kinase to promote DNA replication in Trypanosoma brucei.

Kyu Joon LeeZiyin Li

Published in: BMC biology (2021)

These results identify the CRK2-CYC13 complex as an S-phase regulator in T. brucei and reveal its role in regulating DNA replication through promoting the assembly of the Cdc45-Mcm2-7-GINS complex.

Keyphrases

cell cycle
transcription factor
single cell
signaling pathway
protein kinase
cell death
pi k akt