Kidney tubular injury induced by valproic acid: systematic literature review.

Giulia AnguissolaDennis LeuGiacomo D SimonettiBarbara Goeggel SimonettiSebastiano A G LavaGregorio P MilaniMario G BianchettiMartin Scoglio

Published in: Pediatric nephrology (Berlin, Germany) (2023)

Valproic acid may induce an overt kidney tubular injury, which is associated with a proximal tubular mitochondrial toxicity. Treatment for 7 months or more is often associated with a pauci- or oligosymptomatic kidney tubular injury. A higher resolution version of the Graphical abstract is available as Supplementary information.

Keyphrases

high glucose
oxidative stress
endothelial cells
health information
combination therapy
social media
replacement therapy
smoking cessation