Potential of a glucagon-like peptide-1 receptor/glucose-dependent insulinotropic polypeptide receptor/glucagon receptor triagonist for the treatment of obesity and type 2 diabetes.

Eiichi ArakiMasaji SakaguchiKazuki FukudaTatsuya Kondo

Published in: Journal of diabetes investigation (2022)

Triagonists of GLP-1R/ GIPR /GCGR, including SAR441255, bind to each receptor and induce specific effects through each receptor signaling pathway, thus result in weight loss and glycemic control in obese T2D animal models.

Keyphrases

type diabetes
weight loss
glycemic control
signaling pathway
metabolic syndrome
insulin resistance
blood glucose
bariatric surgery
cardiovascular disease
adipose tissue
epithelial mesenchymal transition
roux en y gastric bypass
blood pressure
binding protein
gastric bypass
high fat diet induced