IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification.

Giulia BerzeroAnna-Luisa Di StefanoSusanna RonchiFranck BielleChiara VillaErell GuillermLaurent CapelleBertrand MathonAlice LaurengeMarine GiryYohann SchmittYannick MarieAhmed IdbaihKhe Hoang-XuanJean-Yves DelattreKarima MokhtariMarc Sanson

Published in: Neuro-oncology (2021)

Our findings highlight the importance of histological grading and molecular profiling for the prognostic stratification of IDHwt gliomas and suggest some caution when assimilating IDHwt grade II gliomas to molecular glioblastomas, especially those with isolated TERT promoter mutation.

Keyphrases

high grade
low grade
dna methylation
single molecule
gene expression
single cell