Genetic variation of ABCB1 (rs1128503, rs1045642) and CYP2E1 rs3813867 with the duration of tuberculosis therapy: a pilot study among tuberculosis patients in Indonesia.
Melisa Intan BarlianaArif Satria Wira KusumaWidya Norma InsaniSofa Dewi AlfianAjeng DiantiniMutakin MutakinTina RostinawatiHerlambang HerlambangIrma Melyani PuspitasariAuliya Abdurrohim SuwantikaRizky AbdulahPublished in: BMC research notes (2021)
The frequency of alleles of each gene was analyzed by Hardy-Weinberg equilibrium. The genetic profiles of ABCB1 rs1128503 and rs1045642 were varied (CC, CT, TT), while CYP2E1 rs3813867 was present in CC (wild type). The genetic variations of ABCB1 and CYP2E1 may have no significant correlation with the duration of TB therapy. Nevertheless, this study may provide as preliminary results for the genetic profiles of ABCB1 (rs1128503, rs1045642) and CYP2E1 (rs3813867) in the Indonesia population.
Keyphrases
- genome wide
- mycobacterium tuberculosis
- end stage renal disease
- copy number
- chronic kidney disease
- emergency department
- ejection fraction
- magnetic resonance imaging
- wild type
- dna methylation
- prognostic factors
- transcription factor
- hepatitis c virus
- mesenchymal stem cells
- positron emission tomography
- molecular dynamics
- patient reported outcomes
- patient reported