Busulfan Interlaboratory Proficiency Testing Program Revealed Worldwide Errors in Drug Quantitation and Dose Recommendations.
Dinemarie KweekelJeannine S McCuneArjen M PuntMatthijs van LuinEric J F FranssenPublished in: Therapeutic drug monitoring (2023)
The proficiency test showed persistent inaccuracies in busulfan quantitation, pharmacokinetic modeling, and dose recommendations. Additional educational efforts have yet to be implemented; regulatory efforts seem to be needed. The use of specialized busulfan pharmacokinetic laboratories or a sufficient performance in busulfan proficiency tests should be required for HCT centers that prescribe busulfan.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- quality improvement
- ms ms
- mass spectrometry
- liquid chromatography tandem mass spectrometry
- acute lymphoblastic leukemia
- emergency department
- transcription factor
- liquid chromatography
- tandem mass spectrometry
- patient safety
- high resolution
- electronic health record
- drug induced
- simultaneous determination
- solid phase extraction