Cell-Free DNA Extracted from CSF for the Molecular Diagnosis of Pediatric Embryonal Brain Tumors.
Mathieu ChicardYasmine IddirJulien Masliah PlanchonValérie CombaretValéry AttignonAlexandra Saint-CharlesDidier FrappazCecile Faure ConterKévin BeccariaPascale VarletDidier FrappazSylvain BaulandeGaelle PierronYassine BouchouchaFrançois DozOlivier O DelattreJoshua J WaterfallFranck BourdeautGudrun SchleiermacherPublished in: Cancers (2023)
CSF cfDNA sequencing yielded informative results in 60% (15/25) of all cases, with informative results in 83% (15/18) of all cases analyzed by WES. These results pave the way for the implementation of these novel approaches for molecular diagnosis and minimal residual disease monitoring.