Association of the IgG N-glycome with the course of kidney function in type 2 diabetes.

Sunny S SinghRalph HeijmansClaudia K E MeulenAloysius G LieverseOlga GornikEric J G SijbrandsGordan LaucMandy van Hoek

Published in: BMJ open diabetes research & care (2021)

In type 2 diabetes, we found IgG N-glycosylation patterns associated with a faster decline of kidney function, reflecting a pro-inflammatory state of IgG. eGFR, but not ACR, was associated with IgG glycans, which suggests these associations may represent renal macroangiopathy rather than microvascular disease.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
insulin resistance
tyrosine kinase
epidermal growth factor receptor
metabolic syndrome
skeletal muscle
weight loss
cell surface