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Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition.

Myrofora PanagiFotios MpekrisChrysovalantis VoutouriAndreas G HadjigeorgiouChloe SymeonidouEleni PorfyriouChristina MichaelAndreas StylianouJohn D MartinHoracio CabralAnastasia ConstantinidouTriantafyllos Stylianopoulos
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Our study suggests the targeting of MCs with clinically administered drugs, such as antihistamines, as a promising approach to overcome resistance to immunotherapy in sarcomas.
Keyphrases
  • high grade
  • patient safety
  • induced apoptosis
  • signaling pathway
  • drug induced