Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition.
Myrofora PanagiFotios MpekrisChrysovalantis VoutouriAndreas G HadjigeorgiouChloe SymeonidouEleni PorfyriouChristina MichaelAndreas StylianouJohn D MartinHoracio CabralAnastasia ConstantinidouTriantafyllos StylianopoulosPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Our study suggests the targeting of MCs with clinically administered drugs, such as antihistamines, as a promising approach to overcome resistance to immunotherapy in sarcomas.