Highly selective two-photon fluorescent off-on probes for imaging tyrosinase activity in living cells and tissues.

Yixin CuiSang Jun ParkXiaofeng WuRui WangSujie Qi Hwan Myung Kim Juyoung Yoon

Published in: Chemical communications (Cambridge, England) (2021)

A coumarin-based two-photon (TP) fluorescent off-on probe has been developed for detecting tyrosinase activity. High selectivity, sensitivity and biocompatibility enable the probes to successfully image tyrosinase activity in live cells and tissues using TP microscopy.

Keyphrases

living cells
fluorescent probe
single molecule
high resolution
gene expression
induced apoptosis
deep learning
oxidative stress
optical coherence tomography
cell cycle arrest
cell proliferation
quantum dots
mass spectrometry
high speed
fluorescence imaging
nucleic acid
monte carlo