Tannic acid alleviates ETEC K88-induced intestinal damage through regulating the p62-keap1-Nrf2 and TLR4-NF-κB-NLRP3 pathway in IPEC-J2 cells.
Wenhui LiuKangkang GuoPublished in: Journal of the science of food and agriculture (2024)
The present study showed that TA reduced the diarrhea rate of weaned piglets by restoring the intestinal mucosal mechanical barrier function, alleviating oxidative stress and inflammation. The underlying mechanism was achieved by modulating the p62-keap1-Nrf2 and TLR4-NF-κB-NLRP3 pathway. © 2024 Society of Chemical Industry.
Keyphrases
- oxidative stress
- induced apoptosis
- diabetic rats
- signaling pathway
- toll like receptor
- inflammatory response
- dna damage
- ischemia reperfusion injury
- immune response
- nuclear factor
- lps induced
- cell cycle arrest
- protein protein
- nlrp inflammasome
- pi k akt
- high glucose
- mouse model
- heat shock
- small molecule
- endoplasmic reticulum stress
- cell death