Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma.

Prit Benny MalgulwarCarla DanussiSharvari DharmaiahWilliam JohnsonAnand SinghKunal RaiArvind RaoJason T Huse

Published in: Neuro-oncology (2023)

Our findings indicate that SIRT2 inhibition selectively targets ATRX-deficient gliomas for senescence through global chromatin remodeling, while demonstrating more broadly a viable approach to combat complex epigenetic rewiring in cancer.

Keyphrases

genome wide
dna damage
dna methylation
gene expression
endothelial cells
transcription factor
oxidative stress
papillary thyroid
copy number
stress induced
high grade
squamous cell
ischemia reperfusion injury
childhood cancer