A DNA Switch for Detecting Single Nucleotide Polymorphism within a Long DNA Sequence Under Denaturing Conditions.

Wenqing ZhangJiuxing LiBruno SalenaYingfu Li

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)

Invited for the cover of this issue is the group of Yingfu Li at McMaster University. The image depicts a molecular switch for ultra-specific detection of DNA utilizing a guanine-quadruplex (up-right structure) resistant to denaturation by urea (ball-and-stick structures). Read the full text of the article at 10.1002/chem.201903536.

Keyphrases

single molecule
circulating tumor
cell free
high resolution
nucleic acid
deep learning
machine learning
real time pcr
solid state