Risk factors for steroid-induced affective disorder in children with leukemia.
Anna C MurielDarcy E BurgersAnnika N TreyballLynda M VroomanEsmeralda AdolfChase SamselPublished in: Pediatric blood & cancer (2020)
Corticosteroids are essential to treating childhood acute lymphoblastic leukemia (ALL), and can cause significant neuropsychiatric side effects. This retrospective chart review is a preliminary exploration of characteristics associated with psychiatry consultation and steroid-induced affective disorder (SIAD) during ALL treatment. Of 125 ALL patients (ages 1-10 years), 56 (44.8%) received psychiatry consultation. Thirty-nine (31.2%) of the total cohort were diagnosed with SIAD. SIAD was significantly associated with family psychiatric history, but not with steroid exposure, CNS radiation, sociodemographic factors, developmental delay, Trisomy 21, or prior psychiatric history. Gathering family psychiatric history may help identify children at increased risk of SIAD.
Keyphrases
- acute lymphoblastic leukemia
- mental health
- end stage renal disease
- high glucose
- diabetic rats
- young adults
- palliative care
- bipolar disorder
- chronic kidney disease
- ejection fraction
- newly diagnosed
- bone marrow
- prognostic factors
- acute myeloid leukemia
- blood brain barrier
- oxidative stress
- endothelial cells
- radiation induced
- radiation therapy
- patient reported outcomes
- patient reported