Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart.
Yuanbiao ZhaoAndrew S RichingWalter E KnightCongwu ChiLindsey J BroadwellYanmei DuMostafa Abdel-HafizAmrut V AmbardekarDavid C IrwinCatherine ProenzaHongyan XuLeslie A LeinwandLori A WalkerKathleen C WoulfeMichael R BristowPeter M ButtrickKunhua SongPublished in: Circulation (2022)
These findings reveal regulation of alternative splicing as a novel mechanism by which a long noncoding RNA controls cardiac function. This study indicates potential therapeutics for heart disease by targeting the long noncoding RNA or pathways regulating alternative splicing.