Association between glucagon-like peptide-1 receptor agonists and risk of suicidality: A comprehensive analysis of the global pharmacovigilance database.

Tae Hyeon KimKyeongmin LeeSeoyoung ParkHanseul ChoJaeyu ParkHyesu JoYejun SonSoeun KimJiseung KangLee SmithMasoud RahmatiGuillaume FondLaurent BoyerDamiano PizzolHayeon LeeSang Youl RheeJiyoung HwangHyunji SangDong-Keon Yon

Published in: Diabetes, obesity & metabolism (2024)

The suspected association between GLP-1RA use and suicidality, as raised by the European Medicines Agency, was not found in our global analysis. This indicates that the sporadic reports of GLP-1RA-associated suicidality are likely influenced by factors such as comorbidities present in the GLP-1RA user population.

Keyphrases

rheumatoid arthritis
adverse drug
disease activity
ankylosing spondylitis
pulmonary embolism
interstitial lung disease
late onset
systemic lupus erythematosus
emergency department
electronic health record
amyotrophic lateral sclerosis