Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity.

Tian LiuYuqi MaHui ZhaoPengli WangYan NiuYuehuan HuXi ShenMingxia ZhangBing YanJun Yu

Published in: Pharmaceutical biology (2023)

HLF plays a protective effect on HU-induced cardiac remodelling by enhancing NPRA-cGMP-PKG pathway and suppressing the calcineurin-NFAT pathway, which provides a theoretical basis for use in clinical therapies.

Keyphrases

left ventricular
nitric oxide
high glucose
diabetic rats
signaling pathway
drug induced
heart failure
endothelial cells
protein kinase
toll like receptor
inflammatory response