Impact of closed loop stimulation on prognostic cardiopulmonary variables in patients with chronic heart failure and severe chronotropic incompetence: a pilot, randomized, crossover study.

Joachim ProffBéla MerkelyRoland PappCorinna LenzPeter NordbeckChristian ButterJuergen MeyerhoeferMichael DoeringDean J MacCarterKatharina IngelThomas ThouetUlf LandmesserMattias J Roser

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)

The data of the present pilot study are compatible with the notion that CLS activation may improve VE slope in CRT patients with severe CI and less advanced heart failure. Further research is needed to determine the long-term clinical outcomes of CLS.

Keyphrases

heart failure
early onset
cardiac resynchronization therapy
left ventricular
drug induced
atrial fibrillation