Altered pathways of keratinization, extracellular matrix generation, angiogenesis, and stromal stem cells proliferation in patients with systemic sclerosis.
Amelia SpinellaDomenico Lo TartaroLara GibelliniMarco de PintoValentina PintoElisa BonettiFrancesca LolliMelba LattanziFederica LumettiGabriele AmatiGiorgio De SantisAndrea CossarizzaCarlo SalvaraniDilia GiuggioliPublished in: Journal of scleroderma and related disorders (2022)
According to our data, RNA-sequencing and pathway analysis revealed that systemic sclerosis subjects display a discrete pattern of gene expression associated with keratinization, extracellular matrix generation, and negative regulation of angiogenesis and stromal stem cells proliferation. Further analysis on larger numbers of patients is needed; however, our findings provide an interesting framework for the development of biomarkers useful to explore potential future therapeutic approaches.
Keyphrases
- systemic sclerosis
- extracellular matrix
- stem cells
- interstitial lung disease
- gene expression
- end stage renal disease
- bone marrow
- endothelial cells
- single cell
- dna methylation
- signaling pathway
- chronic kidney disease
- ejection fraction
- peritoneal dialysis
- vascular endothelial growth factor
- machine learning
- rheumatoid arthritis
- prognostic factors
- climate change
- human health