Variations in mechanical stiffness alter microvascular sprouting and stability in a PEG hydrogel model of idiopathic pulmonary fibrosis.

Julie Leonard-Duke Anthony C Bruce Shayn M Peirce Lakeshia J Taite

Published in: Microcirculation (New York, N.Y. : 1994) (2023)

We have developed a novel, tunable hydrogel assay for the creation of lung explant vessel organoids which can be modulated to study the impact of specific environmental cues on vessel formation and maturation.

Keyphrases

idiopathic pulmonary fibrosis
drug delivery
hyaluronic acid
interstitial lung disease
high throughput
wound healing
tissue engineering
climate change
systemic sclerosis