Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue.
Sophie N SaxtonBen J ClarkSarah B WithersEtto C EringaAnthony M HeagertyPublished in: Physiological reviews (2019)
Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.
Keyphrases
- adipose tissue
- insulin resistance
- type diabetes
- high fat diet
- high fat diet induced
- blood pressure
- metabolic syndrome
- weight loss
- glycemic control
- weight gain
- cardiovascular disease
- skeletal muscle
- cell therapy
- blood glucose
- heart rate
- human health
- hypertensive patients
- physical activity
- body mass index
- bone marrow
- climate change