Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.
Marcelo R de AmorimCamila de S BarbosaTiago A PazLaura P IócaKaren de Jesus NicácioLucianne F P de OliveiraMirian O GoulartJulia M PaulinoMateus O da CruzAntonio G FerreiraMaysa FurlanSimone Possedente de LiraRaquel A Dos SantosAndré RodriguesRafael V C GuidoRoberto G S BerlinckPublished in: Journal of natural products (2023)
Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus Peroneutypa sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites ( 1 , 2 , 4 - 8 ), along with known polyketides ( 3 , 9 - 13 ). Structures of compounds 1 , 2 , and 4 - 8 were established by analysis of spectroscopic data. Absolute configurations of compounds 1 , 2 , 4 , 6 , 7 , and 8 were determined by the comparison of experimental ECD spectra with calculated CD data. Compound 5 exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum .