Trousseau's syndrome triggered by an immune checkpoint blockade in a non-small cell lung cancer patient.
Yuko HorioKoutaro TakamatsuDaisuke TamanoiRyo SatoKoichi SaruwatariTokunori IkedaShunya NakaneMakoto NakajimaSho SaekiHidenori IchiyasuKazuhiko FujiiYusuke TomitaPublished in: European journal of immunology (2018)
PD-1 blockade therapy activates T cells by blocking the interaction between PD-1 and PD-L1 and promotes IFN-γ and Th1 cytokine production. In turn, IFN-γ and Th1 cytokines produced by activated T cells promote TF synthesis in monocytes/macrophages, which results in hypercoagulability leading to thrombosis.