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Trousseau's syndrome triggered by an immune checkpoint blockade in a non-small cell lung cancer patient.

Yuko HorioKoutaro TakamatsuDaisuke TamanoiRyo SatoKoichi SaruwatariTokunori IkedaShunya NakaneMakoto NakajimaSho SaekiHidenori IchiyasuKazuhiko FujiiYusuke Tomita
Published in: European journal of immunology (2018)
PD-1 blockade therapy activates T cells by blocking the interaction between PD-1 and PD-L1 and promotes IFN-γ and Th1 cytokine production. In turn, IFN-γ and Th1 cytokines produced by activated T cells promote TF synthesis in monocytes/macrophages, which results in hypercoagulability leading to thrombosis.
Keyphrases
  • dendritic cells
  • case report
  • immune response
  • pulmonary embolism
  • sensitive detection
  • living cells
  • peripheral blood
  • stem cells