TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling.

Luyang Xiong Irina ZhevlakovaXiaoxia Z WestDetao GaoRakhylia MurtazinaAnthony HorakJonathan Mark Brown Iuliia Molokotina Eugene A Podrez Tatiana V Byzova

Published in: bioRxiv : the preprint server for biology (2023)

Hair follicle stem cells TLR2 is required for hair homeostasis and regeneration. While TLR2 stimulation by endogenous ligand promotes hair growth, reduction in TLR2 and its ligand in aging and obesity may diminish hair growth.

Keyphrases

stem cells
toll like receptor
inflammatory response
immune response
nuclear factor
type diabetes
metabolic syndrome
insulin resistance
mesenchymal stem cells
physical activity
adipose tissue
high fat diet induced