Hydromorphone population pharmacokinetics in pediatric surgical patients.
Rajiv BalyanMin DongValentina PilipenkoKristie GeislerAlexander A VinksVidya ChidambaranPublished in: Paediatric anaesthesia (2020)
After intravenous hydromorphone, plasma pharmacokinetic profiles in children undergoing different surgeries were well described by a two-compartment population allometric pharmacokinetic model using bodyweight as the size descriptor. Model informed simulations identified patient-controlled analgesia parameters to inform initial settings, with adjustments as needed based on observed individual effects.