Thickness of macular inner retinal layers and peripapillary retinal nerve fibre layer in neuromyelitis optica spectrum optic neuritis and isolated optic neuritis with one episode.

Neuromyelitis spectrum optic neuritis (NMOSD-ON) patients had more pRNFL and mRNFL loss compared to ION patients after one episode. Spectral domain optical coherence tomography (SD-OCT) may help to distinguish NMOSD-ON from ION with only moderate diagnostic accuracy.