Identification of distinct cytokine/chemokine profiles in dermatomyositis with anti-transcriptional intermediary factor 1-γ antibody.

Qian Zhao Yongheng Chen Licheng Diao Szeman Cheung Yanting Shih Feng Xue Qunli Xia Hao Li Jie Zheng Hua Cao

Published in: Rheumatology (Oxford, England) (2021)

In anti-TIF1-γ positive DM/CADM, we identified a "skin-predominant" cluster and a "hyperinflammation" cluster based on the cytokine/chemokine profiles. Cytokine/chemokine profiles in anti-TIF1-γ positive DM/CADM can identify discrete clusters of patients with different disease patterns, organ involvements, and clinical outcomes.

Keyphrases

gene expression
transcription factor
skeletal muscle
weight loss
heat shock protein