Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease.

Ilaria BarchettaValentina CeccarelliFlavia A CiminiEugenio BaroneFederica SentinelliMariagrazia ColuzziCaterina ChiappettaLaura BertocciniAntonella TramutolaGiancarlo LabbadiaClaudio Di CristofanoGianfranco SilecchiaFrida LeonettiMaria Gisella Cavallo

Published in: Journal of endocrinological investigation (2020)

This study demonstrates the coexistence of increased plasma DPP4 levels and activity in NAFLD. Circulating DPP4 measurement may represent a novel cost-effective strategy for NAFLD/NASH risk stratification and a potential tool for monitoring disease's progression in established NAFLD.

Keyphrases

metabolic syndrome
type diabetes
insulin resistance
weight loss
body mass index
weight gain
skeletal muscle
adipose tissue
physical activity