Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study.
Suzanne C Dixon-SuenSarah J LewisRichard M MartinDallas R EnglishTerry BoyleGraham G GilesKyriaki MichailidouManjeet K BollaQin WangJoe DennisMichael LushAbctb InvestigatorsThomas U AhearnChristine B AmbrosoneIrene L AndrulisHoda Anton-CulverVolker ArndtKristan J AronsonAnnelie AugustinssonPäivi AuvinenLaura E Beane FreemanHeiko BecherMatthias W BeckmannSabine BehrensMarina BermishevaCarl BlomqvistNatalia V BogdanovaStig E BojesenBernardo BonanniHermann BrennerThomas BrüningSaundra S BuysNicola J CampDaniele CampaFederico CanzianJose E CastelaoMelissa H CessnaJenny Chang-ClaudeStephen J ChanockChristine L ClarkeDon M ConroyFergus J CouchAngela CoxSimon S CrossKamila CzeneMary B DalyPeter DevileeThilo DörkMiriam DwekDiana M EcclesA Heather EliassenChristoph EngelMikael ErikssonD Gareth EvansPeter A FaschingOlivia FletcherHenrik FlygerLin FritschiMarike GabrielsonManuela Gago-DominguezMontserrat García-ClosasJosé A García-SáenzMark S GoldbergPascal GuénelMelanie GündertEric HahnenChristopher A HaimanLothar HäberleNiclas HåkanssonPer HallUte HamannSteven N HartMichelle HarviePeter HillemannsAntoinette HollestelleMaartje J HooningReiner HoppeJohn HopperAnthony HowellDavid J HunterAnna JakubowskaWolfgang JanniEsther M JohnAudrey JungRudolf KaaksRenske KeemanCari M KitaharaStella KoutrosPeter KraftVessela N KristensenKaterina Kubelka-SabitAllison W KurianJames V LaceyDiether LambrechtsLoic Le MarchandAnnika LindblomSibylle LoiblJan LubińskiArto MannermaaMehdi ManoochehriSara MargolinMaria Elena MartinezDimitrios MavroudisUsha MenonAnna Marie MulliganRachel A MurphyNbcs CollaboratorsHeli NevanlinnaInes NevelsteenWilliam G NewmanKenneth OffitAndrew F OlshanHåkan OlssonNick OrrAlpa PatelJulian PetoDijana Plaseska-KaranfilskaNadege PresneauBrigitte RackPaolo RadiceErika Rees-PuniaGad RennertHedy S RennertAtocha RomeroEmmanouil SaloustrosDale P SandlerMarjanka K SchmidtRita K SchmutzlerLukas SchwentnerChristopher ScottMitul ShahXiao-Ou ShuJacques SimardMelissa C SoutheyJennifer StoneHarald SurowyAnthony J SwerdlowRulla M TamimiWilliam J TapperJack A TaylorMary Beth TerryRob A E M TollenaarMelissa A TroesterThérèse TruongMichael UntchCeline M VachonVijai JosephBarbara WappenschmidtClarice R WeinbergAlicja WolkDrakoulis YannoukakosWei ZhengArgyrios ZiogasAlison M DunningPaul D P PharoahDouglas F EastonRoger L MilneBrigid M Lynchnull nullPublished in: British journal of sports medicine (2022)
Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.