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Global Absence and Targeting of Protective Immune States in Severe COVID-19.

Alexis J CombesTristan CourauNicholas F KuhnKenneth H HuArja RayWilliam S ChenSimon J ClearyNayvin W ChewDivyashree KushnoorGabriella C ReederAlan ShenJessica TsuiKamir J Hiam-GalvezPriscila Muñoz-SandovalWandi S ZhuDavid S LeeYang SunRan YouMélia MagnenLauren RodriguezAleksandra LeligdowiczColin R ZamecnikRita P LoudermilkMichael R WilsonChun Jimmie YeGabriela K FragiadakisMark R LooneyVincent ChanAlyssa WardSidney CarrilloMichael MatthayDavid J ErlePrescott G WoodruffCharles LangelierKirsten KangelarisCarolyn M HendricksonCarolyn CalfeeArjun Arkal RaoMatthew F Krummel
Published in: bioRxiv : the preprint server for biology (2020)
In severe COVID-19 patients, the immune system fails to generate cells that define mild disease; antibodies in their serum actively prevents the successful production of those cells.
Keyphrases
  • induced apoptosis
  • sars cov
  • cell cycle arrest
  • coronavirus disease
  • early onset
  • endoplasmic reticulum stress
  • cell death
  • cell proliferation
  • cancer therapy
  • respiratory syndrome coronavirus