Global Absence and Targeting of Protective Immune States in Severe COVID-19.
Alexis J CombesTristan CourauNicholas F KuhnKenneth H HuArja RayWilliam S ChenSimon J ClearyNayvin W ChewDivyashree KushnoorGabriella C ReederAlan ShenJessica TsuiKamir J Hiam-GalvezPriscila Muñoz-SandovalWandi S ZhuDavid S LeeYang SunRan YouMélia MagnenLauren RodriguezAleksandra LeligdowiczColin R ZamecnikRita P LoudermilkMichael R WilsonChun Jimmie YeGabriela K FragiadakisMark R LooneyVincent ChanAlyssa WardSidney CarrilloMichael MatthayDavid J ErlePrescott G WoodruffCharles LangelierKirsten KangelarisCarolyn M HendricksonCarolyn CalfeeArjun Arkal RaoMatthew F KrummelPublished in: bioRxiv : the preprint server for biology (2020)
In severe COVID-19 patients, the immune system fails to generate cells that define mild disease; antibodies in their serum actively prevents the successful production of those cells.