Glycolysis Promotes Angiotensin II-Induced Aortic Remodeling Through Regulating Endothelial-to-Mesenchymal Transition via the Corepressor C-Terminal Binding Protein 1.
Litao WangShuai GuoKaixiang CaoZiling LiZou LiMingchuan SongCailing WangPeiling ChenYing CuiXiaoyan DaiDu FengXiaodong FuJun HeYiming XuPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Our results demonstrate a glycolysis-mediated positive feedback loop of the TGF-β signaling to induce EndoMT and indicate that therapeutically targeting endothelial PFKFB3 or CtBP1 activity could provide a basis for treating EndoMT-linked aortic remodeling.
Keyphrases
- angiotensin ii
- binding protein
- aortic valve
- endothelial cells
- high glucose
- angiotensin converting enzyme
- vascular smooth muscle cells
- pulmonary artery
- left ventricular
- aortic dissection
- stem cells
- bone marrow
- diabetic rats
- transforming growth factor
- transcription factor
- cancer therapy
- drug induced
- coronary artery
- oxidative stress
- pulmonary hypertension
- pulmonary arterial hypertension
- drug delivery