Login / Signup

Glycolysis Promotes Angiotensin II-Induced Aortic Remodeling Through Regulating Endothelial-to-Mesenchymal Transition via the Corepressor C-Terminal Binding Protein 1.

Litao WangShuai GuoKaixiang CaoZiling LiZou LiMingchuan SongCailing WangPeiling ChenYing CuiXiaoyan DaiDu FengXiaodong FuJun HeYiming Xu
Published in: Hypertension (Dallas, Tex. : 1979) (2023)
Our results demonstrate a glycolysis-mediated positive feedback loop of the TGF-β signaling to induce EndoMT and indicate that therapeutically targeting endothelial PFKFB3 or CtBP1 activity could provide a basis for treating EndoMT-linked aortic remodeling.
Keyphrases