Clinical Onset and Multiple Sclerosis Relapse after SARS-CoV-2 Infection.
Antonia PignoloMaria AprileCesare GagliardoGiovanni Maurizio GiammancoMarco D'AmelioPaolo AridonGiuseppe La TonaGiuseppe SalemiPaolo RagonesePublished in: Neurology international (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with several neurological disorders including headache, facial palsy, encephalitis, stroke, demyelinating disorders. The present report will discuss cases of multiple sclerosis (MS) onset and relapse both beginning early after SARS-CoV-2 infection. In both cases, magnetic resonance imaging (MRI) showed widespread bilateral subcortical and periventricular active lesions. Serum IgG against SARS-CoV-2 Spike antigens confirmed seroconversion with titers that are considered not definitely protective against possible reinfection. We hypothesize that SARS-CoV-2 infection, as previously reported for other viruses, could drive an active inflammatory response that can contribute either to the onset of MS or its relapse. The presented data further support the importance of vaccination in individuals with MS.
Keyphrases
- respiratory syndrome coronavirus
- multiple sclerosis
- sars cov
- magnetic resonance imaging
- white matter
- coronavirus disease
- inflammatory response
- mass spectrometry
- free survival
- contrast enhanced
- ms ms
- computed tomography
- big data
- electronic health record
- lipopolysaccharide induced
- toll like receptor
- machine learning
- immune response
- deep learning
- data analysis
- artificial intelligence