Differences in Colistin-resistant Acinetobacter baumannii Clinical Isolates Between Patients With and Without Prior Colistin Treatment.
Yu Jin ParkDuck Jin HongEun Jeong YoonDokyun KimMin Hyuk ChoiJun Sung HongHyukmin LeeDongeun YongSeok Hoon JeongPublished in: Annals of laboratory medicine (2018)
Although prior colistin use did not induce clinical or susceptibility differences, we demonstrated that identification of CR-AB by sequencing is insufficient. We propose that population heterogeneity has a masking effect, especially in colistin non-treated patients; therefore, accurate testing methods reflecting physiological alterations of the bacteria, such as phosphoethanolamine-modified lipid A identification by matrix-assisted laser desorption ionization-time of flight, should be employed.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- drug resistant
- pseudomonas aeruginosa
- gram negative
- klebsiella pneumoniae
- escherichia coli
- newly diagnosed
- single cell
- ejection fraction
- cystic fibrosis
- prognostic factors
- bioinformatics analysis
- patient reported outcomes
- chronic kidney disease
- high resolution
- smoking cessation