DisCanVis: Visualizing integrated structural and functional annotations for better understanding of the effect of cancer mutations located within disordered proteins.

Intrinsically disordered proteins (IDPs) play important roles in a wide range of biological processes and have been associated with various diseases, including cancer. In the last few years, cancer genome projects have systematically collected genetic variations underlying multiple cancer types. In parallel, the number and different types of disordered proteins characterized by experimental methods have also significantly increased. Nevertheless, the role of IDPs in various types of cancer is still not well understood. In this work we present DisCanVis, a novel visualization tool for cancer mutations with a special focus on intrinsically disordered proteins. In order to aid the interpretation of observed mutations, genome level information is combined with information about the structural and functional properties of proteins. The web server enables users to inspect individual proteins, collect examples with existing annotations of protein disorder and associated function or to discover currently uncharacterized examples with likely disease relevance. Through a REST API interface and pre-compiled tables the analysis can be extended to a group of proteins. The web server is freely available for academic researchers at https://discanvis.elte.hu/. This article is protected by copyright. All rights reserved.