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A proposed HLA-B*27 screening method for ankylosing spondylitis detection based on tag-single nucleotide polymorphisms: a preliminary study.

Gabriela Angélica Martínez-NavaYessica Zamudio-CuevasNinoska Aleida Terrazas-OntiverosKarina Martínez FloresRolando Espinosa-MoralesFernando Mijares-DíazShaila Monserrat Juárez-BarretoCarlos Alberto LozadaMargarita Valdés-FloresRoberto Sánchez-SánchezAlberto Hidalgo-BravoJavier Fernández-Torres
Published in: Molecular biology reports (2021)
HLA-B*27 tag-SNPs are associated with AS susceptibility; furthermore, the rs4349859 SNP by its own have an outstanding performance in detecting HLA-B*27 and therefore can be proposed as screening marker in the identification of HLA-B*27 in our population.
Keyphrases
  • ankylosing spondylitis
  • genome wide
  • rheumatoid arthritis
  • disease activity
  • loop mediated isothermal amplification
  • label free
  • real time pcr
  • genetic diversity