Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner.

Tim Wai ShaMichaela WeberDacquin M KasumbaTakeshi NodaMasahiro NakanoHiroki KatoTakashi Fujita

Published in: Virology journal (2020)

These results suggest a novel function of NS1 in improving genome packaging in a dsRNA binding-dependent manner. Taken together, NS1 acts as an essential pro-viral regulator, not only by antagonizing host immunity but also by facilitating viral replication and genome packaging.

Keyphrases

dengue virus
sars cov
genome wide
dna binding
transcription factor
gene expression
dna methylation