Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses-an animal study.
Katharina BomansJudith SchenzSandra TamulyteDominik SchaackMarkus Alexander WeigandFlorian UhlePublished in: Clinical epigenetics (2018)
We can prove that male-but surprisingly not female-descendants of post-sepsis fathers show a dampened systemic as well as pulmonary immune response. Based on this observation of an immune hypo-responsivity, we propose that male descendants of sepsis fathers are at risk to develop fungal and bacterial infections and might benefit from therapeutic immune modulation.