Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.

Claudia GuidaLaura J McCullochMahdieh GodazgarSam D StephenCharlotte BakerDavide BascoJiawen DongDuan ChenAnne ClarkReshma D Ramracheya

Published in: Diabetes, obesity & metabolism (2017)

Local regulation of pancreatic PYY, rather than GLP-1, by DPP-IV inhibition or RYGB can directly modulate the insulin secretory response to glucose, indicating a novel role of pancreatic PYY in diabetes and weight-loss surgery.

Keyphrases

roux en y gastric bypass
weight loss
glycemic control
gastric bypass
type diabetes
bariatric surgery
obese patients
blood glucose
minimally invasive
coronary artery bypass
cardiovascular disease
weight gain
acute coronary syndrome
blood pressure
atrial fibrillation
skeletal muscle
body mass index