B7-H3 promotes nasopharyngeal carcinoma progression by regulating CD8+ T cell exhaustion.

Zhaoen MaGui ChenHao LiSaixuan YangYali XuBolin PanWuping LaiGuangui ChenWenjing LiaoXiaowen Zhang

Published in: Immunity, inflammation and disease (2024)

Our findings suggest that B7-H3 may accelerate tumor growth, tumor cell invasion, and EMT, and interact with 4-1BB to produce CD8+ T cell exhaustion that inhibits tumor immunity. B7-H3 might serve as a novel target for treating NPC.

Keyphrases

growth factor
recombinant human