Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection.

Hongtu CuiYanghui ChenKe LiRui ZhanMingming ZhaoYangkai XuZhiyong LinYi FuQihua HePaul C TangIenglam LeiJifeng ZhangChenze LiYang SunXinhua ZhangTiffany HorngHong S Lu (吕红)Y Eugene ChenAlan DaughertyDaowen WangLemin Zheng

Published in: European heart journal (2021)

Plasma succinate concentrations allow to distinguish patients with AAD from both healthy controls and patients with AMI or PE. Succinate concentrations are regulated by the p38α-CREB-OGDH axis in macrophages.

Keyphrases

aortic aneurysm
mass spectrometry
acute myocardial infarction
genome wide
liquid chromatography
heart failure
gene expression
dna methylation
gas chromatography mass spectrometry
left ventricular
high resolution mass spectrometry