MicroRNA engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling.

Zhixiao YaoJuehong LiHao XiongHaomin CuiJiexin NingShikun WangXingyu OuyangYun QianCunyi Fan

Published in: Journal of nanobiotechnology (2021)

The findings in our study suggest that PTEN/mTOR/TGF-β1 signaling cascades may be a potential pathway for HUMSC-Exos to deliver miR-29a-3p for tendon healing and implicate a novel therapeutic strategy for tendon regeneration via engineered stem cell-derived exosomes.

Keyphrases

stem cells
mesenchymal stem cells
umbilical cord
anterior cruciate ligament reconstruction
cell proliferation
rotator cuff
bone marrow
transforming growth factor
climate change
signaling pathway
risk assessment