MicroRNA engineered umbilical cord stem cell-derived exosomes direct tendon regeneration by mTOR signaling.
Zhixiao YaoJuehong LiHao XiongHaomin CuiJiexin NingShikun WangXingyu OuyangYun QianCunyi FanPublished in: Journal of nanobiotechnology (2021)
The findings in our study suggest that PTEN/mTOR/TGF-β1 signaling cascades may be a potential pathway for HUMSC-Exos to deliver miR-29a-3p for tendon healing and implicate a novel therapeutic strategy for tendon regeneration via engineered stem cell-derived exosomes.