Inhibition of NUPR1-Karyopherin β1 Binding Increases Anticancer Drug Sensitivity.
Chanhee ParkJiwon OhWon Mo LeeHye Ran KohUy Dong SohnSeung Wook HamKyungsoo OhPublished in: International journal of molecular sciences (2021)
Our current findings clearly demonstrate that NUPR1 translocation into the nucleus requires karyopherin β1 binding. Inhibition of the KPNB1 and NUPR1 interaction may constitute a new cancer therapeutic approach that can increase the drug efficacy while reducing the side effects.