Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria.
R GrzankaA Damasiewicz-BodzekAlicja Kasperska-ZającPublished in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2019)
CSU is associated with the activation of the TNF-α/receptors signaling pathway, marked by increased circulating concentrations of TNF-α, sTNF-R1 and sTNF-R2, which are related to each other in this disease. In contrast, the circulating sFas/FasL system is not up-regulated in CSU, and sFas/sFasL may not be a useful marker of the activity/severity of urticarial processes. Considering the lack of significant changes in sFas/sFasL (mainly reflecting systemic apoptosis) in CSU patients, it appears that elevated serum TNF-α concentrations are related to its pro-inflammatory function rather than an enhanced systemic apoptotic response in CSU.
Keyphrases
- rheumatoid arthritis
- signaling pathway
- end stage renal disease
- cell death
- newly diagnosed
- ejection fraction
- chronic kidney disease
- oxidative stress
- magnetic resonance
- peritoneal dialysis
- epithelial mesenchymal transition
- drug induced
- prognostic factors
- endoplasmic reticulum stress
- cell cycle arrest
- magnetic resonance imaging